Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation
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چکیده
منابع مشابه
Transdermal delivery of tolterodine tartrate for overactive bladder treatment: In vitro and in vivo evaluation.
The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential s...
متن کاملTolterodine Tartrate Proniosomal Gel Transdermal Delivery for Overactive Bladder
The goal of this study was to formulate and evaluate side effects of transdermal delivery of proniosomal gel compared to oral tolterodine tartrate (TT) for the treatment of overactive bladder (OAB). Proniosomal gels are surfactants, lipids and soy lecithin, prepared by coacervation phase separation. Formulations were analyzed for drug entrapment efficiency (EE), vesicle size, surface morphology...
متن کاملTransdermal drug delivery treatment for overactive bladder.
Overactive bladder is commonly treated with oral anticholinergic drugs such as oxybutynin chloride. Although oral anticholinergic agents have been effective in controlling urinary urgency and incontinence, adverse events, particularly dry mouth, often cause patients to discontinue oral therapy and to endure incontinence. Oxybutynin can be delivered transcutaneously, maintaining the efficacy of ...
متن کاملSynergistic effect of iontophoresis and chemical enhancers on transdermal permeation of tolterodine tartrate for the treatment of overactive bladder.
PURPOSE The objective of the study was to evaluate the synergistic transdermal permeation effect of chemical enhancers and iontophoresis technique on tolterodine tartrate (TT) transdermal gel and to evaluate its pharmacokinetic properties. MATERIALS AND METHODS Taguchi robust design was used for optimization of formulations. Skin permeation rates were evaluated using the Keshary-chein type di...
متن کاملoxybutynin and tolterodine in a trial for treatment of overactive bladder in iranian women.
objective: to evaluate the efficacy and side effects of oxybutinin in comparison to tolterodine in treatment of overactive bladder (oab) with detrussor overactivity (doa) in iranian women. materials and methods: one hundred iranian old women with clinical symptoms of oab who show ido in the filling cystometry participated in this randomized double-blinded parallel-group by using two kinds of th...
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ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2017
ISSN: 1846-9558
DOI: 10.1515/acph-2017-0027